| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/15/2010 | LA | Glaus | Demoted to reserve roster | | | Before |
| 4/15/2010 | LA | Ludwick | Demoted to reserve roster | | | Before |
| 4/15/2010 | LA | Rodriguez | Promoted to active roster | | | Before |
| 4/15/2010 | LA | Shields | Promoted to active roster | | | Before |
| 4/15/2010 | StL | Coghlan | Demoted to reserve roster | | | Before |
| 4/15/2010 | StL | Gallardo | Promoted to active roster | | | Before |
| 4/15/2010 | StL | Gonzalez,A | Demoted to reserve roster | | | Before |
| 4/15/2010 | StL | Harden | Promoted to active roster | | | Before |
| 4/26/2010 | StL | Beckham | Promoted to active roster | | | Before |
| 4/26/2010 | StL | Scutaro | Placed on disabled list | | 4/23/2010 | Before |
| 5/3/2010 | Chi | Martinez | Placed on disabled list | | 4/30/2010 | Before |
| 5/3/2010 | Chi | Snyder | Promoted to active roster | | | Before |
| 5/6/2010 | LA | Garza | Promoted to active roster | | | Before |
| 5/6/2010 | LA | Rodriguez | Demoted to reserve roster | | | Before |
| 5/10/2010 | StL | Beckham | Demoted to reserve roster | | | Before |
| 5/10/2010 | StL | Scutaro | Activated from disabled list | | | Before |
| 5/10/2010 | Tex | Billingsley | Demoted to reserve roster | | | Before |
| 5/10/2010 | Tex | Cain | Promoted to active roster | | | Before |
| 5/10/2010 | Tex | Escobar,K | Promoted to active roster | | | Before |
| 5/10/2010 | Tex | Lester | Demoted to reserve roster | | | Before |
| 5/17/2010 | Chi | Martinez | Activated from disabled list | | | Before |
| 5/17/2010 | Chi | Snyder | Demoted to reserve roster | | | Before |
| 5/17/2010 | NY | Hawpe | Placed on disabled list | | 5/17/2010 | Before |
| 5/17/2010 | NY | McLouth | Promoted to active roster | | | Before |
| 5/17/2010 | Tex | Drew,S | Promoted to active roster | | | Before |
| 5/17/2010 | Tex | Tulowitzki | Placed on disabled list | | 5/11/2010 | Before |
| 5/27/2010 | Chi | Wagner | Promoted to active roster | | | Before |
| 5/27/2010 | Chi | Zavada | Placed on disabled list | | 5/23/2010 | Before |
| 6/4/2010 | LA | Carpenter | Placed on disabled list | | 5/29/2010 | Before |
| 6/4/2010 | LA | Oswalt | Promoted to active roster | | | Before |
| 6/7/2010 | Chi | Wagner | Demoted to reserve roster | | | Before |
| 6/7/2010 | Chi | Zavada | Activated from disabled list | | | Before |
| 6/7/2010 | NY | Hawpe | Activated from disabled list | | | Before |
| 6/7/2010 | NY | Izturis | Promoted to active roster | | | Before |
| 6/7/2010 | NY | McLouth | Demoted to reserve roster | | | Before |
| 6/7/2010 | NY | Utley | Placed on disabled list | | 5/30/2010 | Before |
| 6/10/2010 | Chi | Johnson,N | Promoted to active roster | | | Before |
| 6/10/2010 | Chi | Teixeira | Placed on disabled list | | 6/10/2010 | Before |
| 6/17/2010 | NY | Izturis | Demoted to reserve roster | | | Before |
| 6/17/2010 | NY | Utley | Activated from disabled list | | | Before |
| 6/17/2010 | StL | Beckett | Placed on disabled list | | 6/17/2010 | Before |
| 6/17/2010 | StL | Danks | Promoted to active roster | | | Before |
| 6/17/2010 | StL | Harden | Placed on disabled list | | 6/16/2010 | Before |
| 6/17/2010 | StL | Peavy | Promoted to active roster | | | Before |
| 6/24/2010 | LA | Oswalt | Demoted to reserve roster | | | Before |
| 6/24/2010 | LA | Rodriguez | Promoted to active roster | | | Before |
| 6/24/2010 | NY | Jimenez | Placed on disabled list | | 6/22/2010 | Before |
| 6/28/2010 | Chi | Johnson,N | Demoted to reserve roster | | | Before |
| 6/28/2010 | Chi | Teixeira | Activated from disabled list | | | Before |
| 7/5/2010 | StL | Beckett | Activated from disabled list | | | Before |
| 7/5/2010 | StL | Danks | Demoted to reserve roster | | | Before |
| 7/5/2010 | StL | Harden | Activated from disabled list | | | Before |
| 7/5/2010 | StL | Peavy | Demoted to reserve roster | | | Before |
| 7/8/2010 | Chi | Greinke | Placed on disabled list | | 7/5/2010 | Before |
| 7/8/2010 | Chi | Wagner | Promoted to active roster | | | Before |
| 7/8/2010 | LA | Carpenter | Activated from disabled list | | | Before |
| 7/8/2010 | LA | Rodriguez | Demoted to reserve roster | | | Before |
| 7/8/2010 | NY | Jimenez | Activated from disabled list | | | Before |
| 7/15/2010 | StL | Beckett | Placed on disabled list | | 7/14/2010 | Before |
| 7/15/2010 | StL | Peavy | Promoted to active roster | | | Before |
| 7/19/2010 | NY | Bloomquist | Promoted to active roster | | | Before |
| 7/19/2010 | NY | Choo | Placed on disabled list | | 7/16/2010 | Before |
| 7/19/2010 | NY | DeJesus | Promoted to active roster | | | Before |
| 7/19/2010 | NY | Molina | Promoted to active roster | | | Before |
| 7/19/2010 | NY | Napoli | Placed on disabled list | | 7/17/2010 | Before |
| 7/19/2010 | NY | Victorino | Placed on disabled list | | 7/18/2010 | Before |
| 7/22/2010 | Chi | Greinke | Activated from disabled list | | | Before |
| 7/22/2010 | Chi | Johnson,J | Demoted to reserve roster | | | Before |